1. About nystatin

Nystatin is an antifungal medicine. It's used to treat or prevent infections caused by a fungus (or yeast). These include:

Nystatin kills the fungus and gets rid of the infection. It can also be used to stop you getting an infection.

Nystatin is only available on prescription.

It comes as a liquid (suspension) that you swirl around your mouth and then swallow. It also comes mixed with steroids, antiseptics or antibacterials as a cream or ointment.

2. Key facts

  • You usually take nystatin liquid 4 times a day after meals and before bedtime.
  • It's important not to eat or drink for 30 minutes after taking the liquid.
  • Nystatin usually starts to work after 2 days.
  • It's important to continue to take or use nystatin for 2 days after your condition is better. This will help to stop it coming back again.
  • Creams and ointments containing nystatin are known by the brand names Trimovate, Timodine or Nystaform HC.

3. Who can and cannot take nystatin

Most adults and children, including babies, can take nystatin liquid or use nystatin cream and ointments.

Nystatin is not suitable for everyone. To make sure nystatin is safe for you, tell a pharmacist or doctor if:

  • you have ever had an allergic reaction to nystatin or any other medicine in the past (including any ingredients in the cream or ointment)
  • you cannot digest some sugars – the liquid has a small amount of sucrose in it
  • you have tuberculosis (TB) of the skin – you may not be able to use the cream or ointment

4. How and when to take nystatin

It's important to take the medicine for as long as your doctor recommends. If you stop taking it too soon, the infection can come back.

Dosage for nystatin liquid

The usual dose (for adults, babies and children) to:

  • treat oral thrush is 1ml, taken 4 times a day. Leave at least 3 hours between doses. If your doctor recommends something different, follow their advice.
  • prevent oral thrush is 1ml, taken once or twice a day

How to take nystatin liquid

People usually take nystatin liquid for around 1 week to treat oral thrush.

It's best to take it after a meal or some food. However, do not mix it with food or water or any other drink.

  1. Shake the bottle well.
  2. Take the lid off and measure out the right amount using an oral syringe, medicine spoon or dropper. Do not use a kitchen teaspoon as it will not give you the right amount.
  3. Put the medicine in your mouth.
  4. Keep it in your mouth for at least 30 seconds if possible, using it like a mouthwash before you swallow it.
  5. Do not eat or drink anything for 30 minutes after taking it. This stops you washing the medicine out of your mouth too soon.

It may be difficult to get your child to keep it in their mouth, but encourage them to do this if you can. Do not worry if they cannot. The medicine will still help even if they swallow it quickly.

Nystatin cream or ointment

Nystatin is also available in creams and ointments mixed with other ingredients. Your doctor will decide which is best for you.

You will usually apply a cream or ointment 2 or 3 times a day, for a maximum of 7 days. The amount you use will depend on the skin condition you have. Your doctor or pharmacist will tell you how much to use and how long to use it for.

What if I forget to take a dose?

If you forget a dose, take it as soon as you remember, unless it's nearly time for your next dose. In this case, just skip the missed dose and take your next one as normal.

Do not take a double dose to make up for a missed dose.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to remember your medicines.

What if I take too much?

Nystatin is generally very safe. Taking too much is unlikely to harm you or your child.

If you're worried, speak to your pharmacist or doctor.

If your nystatin cream or ointment contains a strong steroid called clobetasol, talk to your pharmacist or doctor. They'll be able to tell you if you've used too much.

5. Side effects of nystatin

Like all medicines, nystatin can cause side effects, but most people have no side effects or only minor ones.

Common side effects

If you're taking nystatin liquid, talk to your pharmacist or doctor if these side effects bother you or do not go away:

  • diarrhoea
  • feeling or being sick (nausea or vomiting)

If you're using nystatin cream or ointment, stop using the product and talk to your pharmacist or doctor if:

  • you have a rash or itchy, dry or swollen skin where you have applied it
  • you get a new infection

Your pharmacist or doctor may be able to recommend a different medicine.

Serious allergic reaction

It happens rarely but it is possible to have a serious allergic reaction (anaphylaxis) to nystatin.

These are not all the side effects of nystatin. For a full list, see the leaflet inside your medicine packet.


You can report any suspected side effect to the UK safety scheme.

6. How to cope with side effects of nystatin

What to do about:

  • diarrhoea – drink lots of fluids, such as water or squash. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
  • feeling or being sick – stick to simple meals and do not eat rich or spicy food. If you are being sick, try small, frequent sips of water to avoid dehydration. Make sure you take nystatin liquid after a meal or snack.

7. Pregnancy and breastfeeding

Nystatin and pregnancy

It's usually safe to take nystatin while you're pregnant or trying for a baby.

Talk to your doctor if you're using a nystatin cream or ointment mixed with other ingredients. They will be able to tell you if the other ingredients are safe to use while you're pregnant.

Nystatin and breastfeeding

It's usually safe to take nystatin liquid while you're breastfeeding.

Talk to your doctor if you're using a nystatin cream or ointment mixed with other ingredients. Your doctor will be able to tell you if the other ingredients are safe while you're breastfeeding.

If you're using nystatin cream or ointment on your breasts, wash it off your breasts before feeding your baby. Then wash your hands before you touch your nipple to your baby's mouth.

If your baby is being treated for oral thrush, you can carry on breastfeeding, but you'll need to be treated at the same time. If you have prescribed nystatin cream or ointment, apply it around your nipples after each time you breastfeed.

8. Cautions with other medicines

Nystatin liquid, cream or ointment are generally OK to use when taking other medicines, including painkillers.

Talk to your pharmacist or doctor if you're using a nystatin cream or ointment mixed with other ingredients. They'll be able to tell you if the other ingredients are safe to take with other medicines.

Mixing nystatin with herbal remedies and supplements

There's very little information about taking herbal remedies and supplements with nystatin. They're not tested in the same way as prescription medicines.


Tell a pharmacist or doctor if you're taking any other medicines, including herbal medicines, vitamins or supplements.

9. Common questions about nystatin

Related conditions

Page last reviewed: 02/08/2020
Next review due: 02/08/2023