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Most people are only diagnosed with PBC after having a routine blood test for another reason. Some people have symptoms early on and some may develop them later.

People who have symptoms may experience:

Some people with PBC may also have symptoms of another condition, such as an underactive thyroid (hypothyroidism).

Read about the causes of PBC for more information about related conditions.

Symptoms can range from mild to severe, and this isn’t always related to the degree of liver damage you have.

Some people with PBC have severe symptoms but their liver isn't severely damaged, while others may have significant liver damage but no symptoms or only mild ones.

Advanced PBC

Medication can usually help to delay liver damage in people with PBC, but as the liver slowly becomes more scarred and damaged (eventually ending up with cirrhosis), you may have additional symptoms.

These can include:

Read more about the symptoms of cirrhosis.