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Treatments for CFS/ME aim to help relieve your symptoms.

Your treatment will be tailored to your symptoms. Early diagnosis, taking medicine to control certain symptoms, and making lifestyle changes can all help.

CFS/ME can last a long time, but most people's symptoms will improve with time.

Some people make a full recovery and can return to their previous activities. Others continue to have symptoms or periods when their symptoms get worse.


New guidelines on CFS/ME are currently being developed by NICE. The draft guidelines suggest structured exercise programmes, such as graded exercise therapy (GET) will no longer be recommended to treat CFS/ME.

Once the full guidelines are published we'll update this page to reflect any changes.

Read more information about the draft guidance from NICE.

There's no single way of managing CFS/ME that works for everyone, but there are a number of treatment options.

The National Institute for Health and Care Excellence (NICE) says you should be offered a treatment plan tailored to your symptoms.

Your doctor should discuss all of the options with you, and explain the benefits and risks of any treatment.

They should work with you to develop a treatment plan that suits you and takes into account your circumstances and preferences.

You may need advice about making lifestyle changes, specialist treatments, or a combination of both.

If your symptoms are severe, your doctor should ask a specialist for advice.

Your treatment plan should be reviewed regularly.

There are a number of specialist treatments for CFS/ME.

Cognitive behavioural therapy (CBT)

If you have mild or moderate CFS/ME, you should be offered cognitive behavioural therapy (CBT).

CBT is a talking treatment that can help you manage CFS/ME by changing the way you think and behave.

It can help you to:

  • accept your diagnosis
  • feel more in control of your symptoms
  • challenge feelings that could prevent your symptoms improving
  • gain a better understanding of how your behaviour can affect the condition

Your CBT therapist will ideally have experience of dealing with CFS/ME and treatment will be offered on a 1-to-1 basis.

Using CBT does not mean CFS/ME is considered to be a psychological condition. It's used to treat a variety of long-term conditions.

Graded exercise therapy (GET)

Graded exercise therapy (GET) is a structured exercise programme that aims to gradually increase how long you can carry out a physical activity.

It usually involves exercise that raises your heart rate, such as swimming or walking. Your exercise programme will be adapted to your physical capabilities.

GET should only be carried out with the help of a trained specialist with experience of treating CFS/ME and, if possible, it should be offered on a 1-to-one basis.

After finding out what you can already do comfortably, the length of time you exercise and the intensity will gradually be increased.

As part of your exercise programme, you and your therapist will set goals, such as walking to the shops or doing some gardening. It may take weeks, months or even years for you to achieve these goals, but it's important not to try to do too much too soon.

Activity management

Activity management involves setting individual goals and gradually increasing your activity levels.

You may be asked to keep a diary of your current activity and rest periods to establish your baseline. Activities can then be gradually increased in a way you find manageable.


There's no specific medicine for treating CFS/ME, but medicine can be used to relieve some of the symptoms.

Over-the-counter painkillers can help ease headaches, as well as muscle and joint pain. A GP can prescribe stronger painkillers, although they should only be used on a short-term basis.

You may be referred to a pain management clinic if you have long-term pain.

Antidepressants can be useful for people with CFS/ME who are in pain or having trouble sleeping. Amitriptyline is a low-dose tricyclic antidepressant that may be prescribed to help ease muscle pain.

NICE has more information and advice about specialist CFS/ME care.

As well as specialist treatments for CFS/ME, making lifestyle changes can also help.

Diet and supplements

It's important you eat regularly and have a healthy, balanced diet. You should be offered practical advice about how to achieve this if, for example, your CFS/ME symptoms are making it difficult for you to shop or prepare food.

If you feel sick (nauseous), eating starchy foods, eating little and often, and sipping drinks slowly may help. If this does not work, medicine can be prescribed.

Diets that exclude certain food types are not recommended for people with CFS/ME. There's also insufficient evidence to recommend supplements, such as vitamin B12, vitamin Cmagnesium, or co-enzyme Q10.

Sleep, rest and relaxation

You may have sleep problems that make your CFS/ME symptoms worse. For example, you may:

  • have problems getting to sleep
  • have unrefreshing or restless sleep
  • need an excessive amount of sleep
  • sleep during the day and be awake at night

You should be given advice about how to establish a normal sleeping pattern. Having too much sleep does not usually improve the symptoms of CFS/ME, and sleeping during the day can stop you sleeping at night.

You should change your sleep pattern gradually, and your doctor should review how it's going regularly. If your sleep does not improve after making changes, you may have an underlying sleep problem that will need to be addressed.

It's likely you'll need to rest during the day, and your doctor should advise you about the best way to do this. For example, they may suggest limiting each rest period to 30 minutes and teach you relaxation techniques, such as breathing exercises.

If you have severe CFS/ME and need to spend much of your time in bed, it can cause problems, including pressure sores and blood clots. These problems, and how to avoid them, should be explained to you and your carers.

Other lifestyle changes to manage CFS/ME

Other ways to manage CFS/ME include:

  • equipment – some people may need a blue badge for parking, a wheelchair, a stairlift, or other adaptations for their home
  • changes in your place of work or study – when you're ready and well enough to return to work or studies, your doctor should be able to advise you on changes that could ease your return

There's limited or no evidence to recommend:

  • pacing – this is a technique that many people with CFS/ME find helpful for managing their symptoms; the general aim is to balance rest and activity to avoid making your fatigue and other symptoms worse, but there has not been enough research into pacing to confirm whether it improves CFS/ME or has any risks
  • resting completely – there's no evidence this helps
  • complementary medicine – there is not enough evidence that it's helpful for CFS/ME

You should not take up vigorous unsupervised exercise such as going to the gym or for a run as this may make your symptoms worse.

NICE has more information on managing CFS/ME

A setback or relapse is when your symptoms get worse for a period of time.

They're a common part of CFS/ME and can be caused by a number of factors, such as an infection or an unplanned activity. Sometimes there's no clear cause.

The doctors treating you can help you manage a setback or relapse by:

  • including more breaks with your current levels of activities
  • teaching you relaxation and breathing techniques
  • encouraging you to be optimistic about your recovery

NICE has more information and advice about managing setbacks and relapses.