Sickle cell disease is the name for a group of inherited health conditions that affect the red blood cells. The most serious type is called sickle cell anaemia.
Sickle cell disease is particularly common in people with an African or Caribbean family background.
People with sickle cell disease produce unusually shaped red blood cells that can cause problems because they do not live as long as healthy blood cells and can block blood vessels.
Sickle cell disease is a serious and lifelong health condition, although treatment can help manage many of the symptoms.
People born with sickle cell disease tend to have problems from early childhood, although some children have few symptoms and lead normal lives most of the time.
The main symptoms of sickle cell disease are:
Some people also experience other problems, such as delayed growth, strokes and lung problems.
Sickle cell disease is caused by a gene that affects how red blood cells develop.
If both parents have the gene, there's a 1 in 4 chance of each child they have being born with sickle cell disease.
The child's parents often will not have sickle cell disease themselves and they're only carriers of the sickle cell trait.
Sickle cell disease is often detected during pregnancy or soon after birth.
Screening for sickle cell disease in pregnancy is offered to all pregnant women in England to check if there's a risk of a child being born with the condition, and all babies are offered screening as part of the newborn blood spot test (heel prick test).
Blood tests can also be carried out at any age to check for sickle cell disease or see if you're a carrier of the gene that causes it.
People with sickle cell disease need treatment throughout their lives. This is usually delivered by different health professionals in a specialist sickle cell centre.
It's also important for people with sickle cell disease to look after their own health using self care measures, such as by avoiding triggers and managing pain.
A number of treatments for sickle cell disease are available.
The only cure for sickle cell disease is a stem cell or bone marrow transplant, but they're not done very often because of the risks involved.
Sickle cell disease varies between individuals from mild to serious, but most people with it lead happy and normal lives.
Mild sickle cell disease may have no impact on a person's day-to-day life.
But the illness can be serious enough to have a significant effect on a person's life.
It can lead to health problems like strokes, serious infections and lung problems, which can occasionally be fatal.
Overall, the life expectancy for someone with sickle cell disease tends to be shorter than normal, but this can vary depending on the exact type of sickle cell disease they have, how it's treated and what problems they experience.
A carrier of sickle cell is someone who carries the gene that causes sickle cell disease but does not have sickle cell disease themselves. It's also known as having the sickle cell trait.
People with the sickle cell trait will not develop sickle cell disease, but are at risk of having a child with it if their partner is also a carrier.
You can request a blood test to check if you carry the sickle cell trait from your GP surgery or the nearest sickle cell and thalassaemia centre.
Finding out as much as possible about sickle cell disease may help you feel more in control of your illness.
The Sickle Cell Society is a UK charity for people with sickle cell disease.
Their website has a wide range of useful information, including news about research into the disorder.