Babies with androgen insensitivity syndrome (AIS) will have XY (usual male pattern) chromosomes. Their external genitals will either appear as female or have an appearance that is not usual for a boy or girl.
There are 2 main types of AIS, which affect people in different ways:
CAIS is not usually obvious from birth because affected babies have female genitals, including a vagina and labia (folds of skin either side of the vaginal opening).
The first signs usually begin at puberty, which starts at around the age of 11 or 12.
When a girl with CAIS reaches puberty, she will:
Girls with CAIS do not have a womb or ovaries, so are unable to get pregnant. Their vagina will also be shorter than normal, which may make some sexual acts difficult.
The development of children with PAIS can vary.
In many cases, the genitalia at birth is the first sign and affected babies may have:
Children with PAIS are often raised as boys, although they will continue to have a small penis and may develop some breast tissue at puberty.
Some children with PAIS are raised as girls.
Like those with CAIS, people with PAIS do not have a womb or ovaries and will be infertile.