Acromegaly is a rare condition where the body produces too much growth hormone, causing body tissues and bones to grow more quickly.
Over time, this leads to abnormally large hands and feet, and a wide range of other symptoms.
Acromegaly is usually diagnosed in adults aged 30 to 50 but can affect people of any age. When it develops before puberty, it's known as "gigantism".
Acromegaly can cause a wide range of symptoms, which tend to develop very slowly over time.
Early symptoms include:
Children and teenagers will be abnormally tall.
As time goes on, common symptoms include:
Symptoms often become more noticeable as you get older.
See your GP straight away if you think you have acromegaly.
Acromegaly can usually be successfully treated, but early diagnosis and treatment is important to prevent the symptoms getting worse and reduce the chance of complications.
If you do not get treatment, you may be at risk of developing:
Because of the risk of bowel polyps, a colonoscopy might be recommended for anyone diagnosed with acromegaly, and regular colonoscopy screening may be necessary.
Acromegaly happens because your pituitary gland (a pea-sized gland just below the brain) produces too much growth hormone.
This is usually caused by a non-cancerous tumour in the pituitary gland called an adenoma.
Most of the symptoms of acromegaly are due to the excess of growth hormone itself, but some come from the tumour pressing on nearby tissues. For example, you may get headaches and vision problems if a tumour pushes against the nearby nerves.
Acromegaly does sometimes run in families, but most of the time it's not inherited. Adenomas usually spontaneously develop because of a genetic change in a cell of the pituitary gland. This change causes uncontrolled growth of the affected cells, creating the tumour.
In rare cases, acromegaly is caused by a tumour in another part of the body, such as the lungs, pancreas or another part of the brain. It may also be linked to some genetic conditions.
The type of treatment offered for acromegaly depends on the symptoms you have. Usually the goal is to:
Most people with acromegaly will have a pituitary tumour that needs to be surgically removed. Medication or radiotherapy may sometimes be needed after, or instead of, surgery.
Surgery is effective in most people and can completely cure acromegaly. But sometimes the tumour is too large to be removed entirely, and you may need another operation or further treatment with medication or radiotherapy.
Under general anaesthetic, the surgeon will make a small cut inside your nose or behind your upper lip to access the pituitary gland.
A long, thin, flexible tube with a light and video camera at one end, called an endoscope, is fed into the opening so your doctor can see the tumour. Surgical instruments are passed through the same opening and used to remove the tumour.
Removing the tumour should instantly lower your levels of growth hormone and relieve pressure on the surrounding tissue. Often, facial features start to return to normal and swelling improves within a few days.
With surgery, there is risk of:
Your surgeon will discuss these risks with you and answer any questions you have.
If your levels of growth hormone are still higher than normal after surgery, or surgery wasn't possible, you may be prescribed medication.
Three different types of medicine are used:
Each of these medications has different advantages and disadvantages. Speak to your doctor about the options available to you, and the benefits and risks of each.
If surgery isn't possible, not all of the tumour could be removed or medication hasn't worked, then you may be offered radiotherapy.
This can eventually reduce your growth hormone levels, but it may not have a noticeable effect for several years and you may need to take medication in the meantime.
Two main types of radiotherapy are used to treat acromegaly:
Stereotactic radiotherapy is more commonly used to treat adenomas because it minimises the risk of damage to nearby healthy tissue.
Radiotherapy can have a number of side effects. It will often cause a gradual drop in the levels of other hormones produced by your pituitary gland, so you'll usually need hormone replacement therapy for the rest of your life. It may also have an effect on your fertility.
Your doctor will be able to talk to you about these risks and other possible side effects.
Treatment is often effective at stopping the excessive production of growth hormone and improving the symptoms of acromegaly.
After treatment, you'll need regular follow-up appointments with your specialist for the rest of your life. These will be used to monitor how well your pituitary gland is working, check you're on the correct hormone replacement treatment and make sure the condition does not return.
Because the symptoms of acromegaly often develop gradually over several years, you may not get a diagnosis straight away. Your doctor may ask you to bring in photographs of yourself that span the past few years to look for the tell-tale gradual changes.
If your doctor suspects you have acromegaly, you will need to have a blood test to measure your growth hormone levels.
To make sure the blood test gives an accurate result, you may be asked to drink a sugary solution before having a series of blood samples taken. For people without acromegaly, drinking the solution should stop growth hormone being released. In people with acromegaly, the level of growth hormone in the blood will remain high. This is called a glucose tolerance test.
Your doctor will also measure the level of another hormone, called insulin-like growth factor 1 (IGF-1). A higher level of IGF-1 is a very accurate indication that you might have acromegaly.
If your blood tests show a high level of growth hormone and IGF-1, you might have an MRI scan of your brain. This will show where the adenoma is in your pituitary gland and how big it is. If you can't have an MRI scan, a CT scan can be carried out, but this is less accurate.
If you have acromegaly, your clinical team will pass information about you on to the National Congenital Anomaly and Rare Diseases Registration Service (NCARDRS).
This helps scientists look for better ways to prevent and treat this condition. You can opt out of the register at any time. Find out more about the register.